Objective：To investigate the effects of different scanning methods and medication with different computed tomography （CT） devices on subjects and their nursing care during coronary angiography. Methods：Based on the coronary computed tomography angiography（CCTA） guidebooks，subjects were divided into the group A and group B. Group A had scanning scheme a of the comput－ed tomography angiography（CTA） using the 2016 Siemens second-generation dual-source CT device in our hospital and medication in accordance with nurses’ experience；group B had scanning scheme b of coronary CTA using 2017 General Electrical（GE） wide detec－tor CT device in our hospital and medication based on iodine flow rate. The one-time examination success rate，contrast agent ex－travasation，adverse reaction rate，and the satisfaction of the subjects were observed. The difference was considered statistically signifi－cant if P<0.05. Results：Requirements for subjects’ cooperation，subjects’ individual factors，failure rate，rescanning rate and the inci－dence of contrast agent extravasation in the group B were lower than those in the group A；satisfaction degree in the group B was higher than that in the group A；all differences had statistical significance（P<0.05）. However，the incidence of adverse reactions in two groups had no statistically significant difference（P>0.05）. Conclusion：GE wide detector device combined with the iodine flow rate has low requirement for subjects’ cooperation and high one-time success rate，which can effectively improve the patients’ satisfaction degree and simplify the nursing process， worthy of promotion and application in clinical medical laboratory.