Polyetheretherketone（PEEK），a linear aromatic and semicrystalline polymer，has excellent mechanical properties and good wear resistance and corrosion resistance. Furthermore，its elastic modulus is highly close to that of the cortical bone. It is an appropriate implant material in vivo. Since the 1980s，as a new implant material，PEEK has been widely used in several orthopedic surgeries such as interbody fusion，artificial joint replacement，and trauma implantation，and has attracted widespread attention in stomatology. Its clinical application over years shows that the PEEK interbody fusion cage has good stability and high fusion rate；the PEEK artificial joints show good tribological properties，fewer wear particles，and strong biological inertia. PEEK has the advantage of individualized manufacture for trauma implants. Using 3D printing technology，a complex prosthesis can be made more rapidly，safely，effectively，and accurately and the new bone induced by the formed scaffold material is as tough and tensile as the natural bone. PEEK has become a new material in stomatology and has attracted wide attention in the fields of oral prosthetics and oral implants. This article aims to review the progress in the clinical application of PEEK and provide a basis for its clinical application.