Objective:To explore the risk factors for coronary heart disease in Chongqing area.Methods：A total of 1 834 consecutive patients who had been diagnosed as coronary heart disease（CHD）（n=1 169) or non-CHD（n=665）by coronary angiography between October 2008 and April 2011 were studied retrospectively.The percentage

level and ratio of each risk factor were analyzed and compared

the correlative factors of CHD were screened by multi-factor logistic regression analysis.Results：1.The percentages of male

family history of CHD

diabetes mellitus（DM）

hypertension

smoking

hyperuricemia and hyperfibrinogenemia were significantly higher in CHD group than those in non-CHD group（all P<0.01）.The levels of age

systolic blood pressure(SBP)

pulse pressure(PP)

hypertension duration

WBC count

apolipoprotein B（apoB）

serum creatinine（Scr）

blood urea nitrogen（BUN）

serum uric acid(SUA)

plasma fibrinogen（FIB）

fasting capillary whole blood glucose

and 2-hour postprandial capillary blood glucose were significantly higher in CHD group than those in non-CHD group（all P<0.01）.The levels of high density lipoprotein cholesterol（HDL-C) and apolipoprotein AI（apoAI）were significantly lower in CHD group compared with those in non-CHD group(all P<0.01).The ratios of TC/HDL-C

TG/HDL-C

LDL-C/HDL-C

apoB/apoAI were significantly higher in CHD group than those in non CHD group（all P<0.01）.There were no significantly differences in obesity

diastolic blood pressure(DBP)

triglyceride(TG)

total cholesterol（TC）

or low-density lipoprotein cholesterol（LDL-C）between the two groups（P>0.05）.2.The multi-factor Logistic regression analysis showed that all the parameters of male

family history of CHD

DM

hypertension

smoking

hyperfibrinogenemia

age

WBC count and apoB were significantly positively correlated with CHD(β＝0.496

1.149

0.595

0.592

0.953

0.282

0.050

0.155 and 1.488

respectively，all P<0.01)

and HDL-C was significantly negatively correlated with CHD（β＝－0.575

P<0.05).Conclusion:1.Male

family history of CHD

diabetes mellitus

hypertension

smoking

hyperfibrinogenemia

age

WBC count

and apoB are significantly positively correlated with CHD in Chongqing area; HDL-C is significantly negatively correlated with CHD.They play an important role in occurrence and progression of coronary heart disease.2.Reducing the level of apoB

increasing the level of HDL-C

controlling DM and hypertension and quitting smoking may be the effective measures to reduce the morbidity and to improve the prognosis of CHD in this area.