Objective：To be compared to the clinical efficacy of sufentanil or remifentanil by target-controlled infusion（TCI） on gyne－cologic laparoscopy surgery. Methods：A total of 92 ASA I or II patients undergoing elective gynecologic laparoscopy operation were randomly divided into tow groups: sufentanil group （group S，n=46） and remifentanil group （group R，n=46）. Sufentanil of group S was administered by TCI at a target effect-site concertration of 0.5 ng/ml and propofol was 3 μg/ml during induction of anesthesia. Sufentanil of group S was administered by TCI at a target effec-site concertration of 0.3 ng/ml and propofol was 3 μg/ml during main－tenance of anesthesia. Remifentanil of group R was administered by TCI at a target blood concertration of 4 ng/ml and propofol was 3 μg/ml during induction of anesthesia. Remifentanil of group R was administered by TCI at a target blood concertration of 4 ng/ml and propofol was 3 μg/ml during maintenance of anesthesia.Systolic blood pressure（SBP），diastolic blood pressure（DBP）and heart rate（HR） at the time of preanesthesia（T0），3 min after induction（T1），intubation（T2），incision（T3），exploration with laparoscopy （T4） and extubation（T5） were recorded. The time from recovery profiles after operation were compared. Propofol of two groups were counted. Results：HR of two groups at T1 were lower those at T0（P＜0.05）， while at T1 SBP and DBP of group R were lower those of group S（P＜0.05）；SBP，DBP and HR of two groups were on different at T2，T3 and T4（P＞0.05）；SBP，DBP and HR of group R at T5 were high－er those of group S（P＜0.05）；The time of group R from stoping infusion to extubation was lower that of group S（P＜0.05），while recov－ery profiles of group S after operation were better than those of group R. Conclusion：Perioperation sufentanil or remifentanil by TCI on gynecologic laparoscopy operation are hemodynamics stability both，but the patients of remifentanil by TCI shoud give opioid drugs ahead the time termination operation.