Objective:To investigate the drug treatment and non-drug treatment for vasovagal syncope (VVS) with different influence factors.Methods:Totally 54 patients (30 females and 24 males) with VVS diagnosed by head-up tilt testing were randomly divided into non drug treatment group

β-blocker treatment group and placebo group based on the sex.The incidences of VVS at different periods of the treatment and for different sexes were analyzed during the 12 months’ follow-up.Results:The long-term efficacy of the drug treatment for VVS was not satisfactory

however that of the non-drug treatment is good

although not obvious at short-term.The drug treatment was effective for females while the non drug treatment was conducive to both sexes.Conclusion:The study reveals the effects of different treatments methods on the incidences of VVS in different sexes

which may propose new individualized treating programs for VVS in clinics and provide references for evidence based medicine.