Objective：To explore the feasibility of high-intensity focused ultrasound（HIFＵ） treatment for breast fibroma accompanied with hyperplasia of mammary glands. Methods：Nine patients diagnosed as breast fibroma accompanied with hyperplasia of mammary glands accepted HIFU treatment and then breast ultrasonography or mammography to follow up changes of pain and nodules’ size in the breast. Results：Pain in nine patients was relieved to varying degrees within three months. Curative effect was sustained for 12 to 24 months（average of 16 months）. Conclusions：It is safe and effective to ablate breast fibroma with HIFU，which is a new approach to treating hyperplasia of mammary glands and relieving breast pain obviously.