Objective：To observe the effectiveness and safety of applying continuous epidural block combined with basal anesthesia in pediatric inguinal region operation. Methods：Totally 60 children requiring operation in inguinal region were randomly divided into group A and group B. Continuous epidural block anesthesia combined with basal anesthesia was used in group A while Ketamine in－tramuscular basal anesthesia combined with Ketamine and Midazolam intravenous anesthesia was applied in group B. Results：The operation was successful in both groups. The Ketamine dosage and adverse reaction in reviving period were better in group A than in group B with statistical significances（P＜0.01）. Conclusions：With advantages of quicker postoperative awaking time，lower cost and safety，pediatric continuous epidural block combined with basal anesthesia is worth popularizing.