Objective：To evaluate the reliability and validity for Chinese version of pediatric quality of life inventoryTM 3.0 neu－romuscular module（PedsQLTM 3.0 NMM）. Methods：The standard procedure of cross-culture adaptation was used to develop the Chi－nese version PedsQLTM 3.0 NMM. Thirty-nine children with Duchenne muscular dystrophy（DMD） and their parents were investigated with the Chinese version scale. The feasibility，reliability and validity of the Chinese version scale were then evaluated. Results：Total－ly 39 copies of questionnaires were completed. The rates of item missing were 0.31% and 0.64%，less than 1%. Total and all dimen－sion’s Cronbach alpha coefficients were ranged between 0.74 and 0.88，all larger than 0.7 and the intraclass correlation coefficient（ICC） was ranged between 0.74 and 0.86，all larger than 0.6. The item in the PedsQLTM 3.0 NMM was moderately and highly related with correlation coefficient of Spearman（0.42～0.88 and 0.39～0.84） in its belonged domains than in other domains. Significant dif－ferences were observed in domains of disease with different severities（P<0.05） but no significant difference was observed in other domains（P >0.05）. Confirmatory factor analysis showed that the comparative fit indexes were 0.94 and 0.93. Conclusions：The Chi－nese version PedsQLTM 3.0 NMM has acceptable psychometric properties. The instrument may be a valuable tool to measure health-related quality of life（HRQOL） of Chinese children with neuromuscular diseases.