Objectives：To identify the risk factors for the sequelae in children with mycoplasma pneumonia pneumonia（MPP） and to provide instructions for the clinical therapy to minimize the risks of the sequelae. Methods：Clinical data of 875 children with MPP from September 2007 to September 2010 in the Children’s Hospital，Chongqing Medical University were retrospectively reviewed. Based on the findings of X-ray and/or CT scan，the subjects were divided into two groups：sequelae group（n=58） and control group（n=60）. Comparison was made between the two groups in age，fever course，wheeze，pleural effusion，complications，manifestation of pneumonia on X ray and/or CT scan，white blood cell count and C-reaction protein. Results：Incidences of fever course lasting more than 10 d，large pleural effusion，pneumonia located at the right upper lung，large patchy shadow and multiple system damage out of the lung were significantly higher in sequelae group than in control group（P<0.05）. Conclusions：Long fever course，large pleural effusion，pneumonia located at the right upper lung，large patchy shadow in the lung，multiple system damage out of the lung are the clinical risk factors for sequelae of MPP.