Objective To observe the expression of interleukin13 (IL13) in Peripheral circulating of polycystic ovary syndrome (PCOS) patients

and analyze the relevance with the body mass index (BMI)

reproductive relevant hormone

fasting blood glucose (FBG) and blood fat. Methods Clinical control trial was carried out. All objects of study were assigned to three groups: PCOS with obesity (40 cases)

PCOS with non-obesity (35 cases) and normal control (39 cases). The body weight

body height

waist circumference and hip circumference were measured and BMI and waist/hip ratio (WHR) were calculated. ELISA kit for IL-13 was used to test the expression in peripheral circulating. Chemiluminescence’s method was applied to detect FBG

fasting insulin (Ins)

cholesterol (TC)

triglycerides (TG)

high-density lipoprotein (HDL) and low-density lipoprotein (LDL) level for the three group objects. Reproductive hormones including follicle-stimulating hormone (FSH)

corpus luteum erythropoietin (LH)

estradiol (E2)

progesterone (P)

prolactin (PRL) and testosterone (T) were assayed by Radiation immunoassays (RI). Results The blood level of IL13 in PCOS with obesity was higher than that in PCOS with non-obesity (P = 0.000)

and there were significance for both of all compared with that in normal control group (P = 0.000；P = 0.019). Ins

LDL

HDL

TG

TC

IR

E2

FSH and P serum levels were no statistical difference; and WHR

BMI

FBG

LH and T index serum value

both of the PCOS with obesity group and PCOS non-obesity group are higher than those in the control group. There was a moderate correlation for IL13 with BMI(R=0.527

P=0.000) and low-grade correlation with FBG (R=0.449

P=0.000) and T (R=0.452

P=0.000). Conclusion Inflammatory marker IL13 in the peripheral blood PCOS patients increased significantly

and has a positive correlation with BMI

FBG and T indexes.