Objective：To investigate the clinical efficacy of three-dimensional conformal radiotherapy combined with XELOX（oxali－platin+capecitabine） program chemotherapy for local recurrence after esophagectomy of esophageal cancer. Methods：A total of 69 cas－es with local recurrence after esophagectomy were randomly divided into treatment and control groups. In treatment group，35 patients received concurrent three-dimensional conformal radiotherapy and XELOX program chemotherapy. In control group，34 patients re－ceived XELOX program chemotherapy. Results：There was no statistically significant difference in general information between treat－ment group and control group. Response rates（RR） of treatment group and control group were 85.7% and 61.8%，with statistically sig－nificant differences（c2=5.130，P=0.024）. One-year survival rates of treatment group and control group were 65.7% vs. 41.2%（c2=4176，P=0.041），and 2-year survival rates of two groups were 45.7% vs. 20.6 %（c2=4.900，P=0.027），with statistically significant differences between two groups. There was no statistically significant difference in incidences of nausea，vomiting and leukopenia，anemia and thrombocytopenia between treatment group and control group（c2=0.206，P=0.650；c2=0.008，P=0.930；c2=0.174，P=0.676；c2=1.052，P=0.305）. Conclusions：Three-dimensional conformal radiotherapy concurrent with XELOX program chemotherapy can im－prove recent efficacy and long-term survival of patients with local recurrence after esophagectomy of esophageal cancer and reduce the side reactions.