Objective：To reveal the effect of cold and dry environment on hyaluronan and laminin in the model of chronic obstructive pulmonary disease（COPD） so as to provide references for treating COPD with local peculiarity of Xinjiang（northwest of China）. Methods：COPD model was established by dripping porcine pancreatic elastase（PEE） in the trachea combined with cigarette smoking and model of COPD cold-dryness was also set up by dripping PEE in the trachea，cigarette smoking combined with cold and dry en－viroment. Bronchial alveolar lavage fluid（BALF） and serum were taken to detect contents of hyaluronan and laminin in rat’s BALF and laminin in rat’s serum of each group with enzyme-linked immunoadsordent assay（ELISA）. The data were analyzed statistically with software SPSS. Results：The results showed that laminin content in serum was significantly higher in COPD cold-dryness group than in control group（P<0.01），but the difference was of no statistical significance between COPD group and control group. Laminin content in BALF was significantly higher in COPD cold-dryness group than in control group（P<0.05），but the difference was of no statistical significance between COPD group and control group. Conclusions：The lung performances of COPD model and COPD cold-dryness model are in accordance with the physiological characteristics of COPD，but laminin contents in serum and BALF are differ－ent，which may be one of the pathogenesis of COPD under the cold and dry environment of northwest china.