Objective：To observe the morphology of left ventricle and changes in myocardial perfusion of peripartum cardiomyopathy （PPCM） before and after treatment by 99mTc-MIBI SPE MPI. Methods：Twenty-seven female patients with PPCM averaged 19-38 year-old were enrolled. Treatment preventing cardiac failure and ventricular remodeling were performed on them. 99mTc-MIBI SPE MPI was applied at one month（（29.41±2.95） d） after the treatment. Eleven patients were followed-up for six months（（6.31±0.84）months）. Left ventricle was divided into 17 segments and semi quantitative assessment was performed to evaluate the morphology of left ventri－cle，perfusion defect range and changes in left ventricular segmental score before and after the treatment. Results：Left ventricular size was decreased in 23 patients（85%），perfusion defect range was decreased（P=0.001） and myocardial perfusion was increased in all left ventricular segments except basal segment of anterior wall and basal segment of posterior wall（Pmax=0.024） at early stage of treat－ment compared with those before treatment. Left ventricular size was normal in 7 patients（64%），perfusion defect range was further decreased in 11 patients（P=0.009） and myocardial perfusion was further increased（Pmax=0.048） after 6 months’ treatment compared with those before treatment. Conclusion：99mTc-MIBI SPE MPI can be used to assess treatment in patients with peripartum cardiomy－opathy.