Objective：To investigate the effects of enteral nutrition（EN） agent of Ensure Nutrison on nutrition indicators for elderly patients with nasal feeding. Methods：Totally 41 hospitalized elderly patients in department of geriatrics in the First Affiliated Hospi－tal of Chongqing Medical University from February 2011 to December 2011 were enrolled. The self-made enteral nutrition（SMEN） was applied for 30 d through nasogastric tube and Ensure Nutrison was applied for 30 d to ensure the targeted caloric of 104.6 kJ[25 kcal/（kg·d）] .Hemoglobin（HGB），total lymphocyte count（TLC），serum total protein（TP），serum albumin（ALB），pre-albumin（PA），serum creatinine（Cr），blood urea nitrogen（BUN） and calculated nitrogen balance（NB） were detected；the waist and hip circumfer－ences and mid-arm circumference（MAC），triceps skin-fold thickness（TSF） were measured and mid-arm muscle circumference（MAMC） was calculated before SMEN nasal feeding，at 15 d，30 d after SMEN nasal feeding and at 15 d，30 d after Ensure Nutrison nasal feeding. Results：At 30 d after SMEN nasal feeding，the levels of TLC，ALB and PA were significantly lowered compared with those before SMEN nasal feeding（P<0.05），but there was no significant difference among other nutrition indicators. At 15 d after En－sure Nutrison nasal feeding，the levels of PA，ALB，HBG and Cr were significantly higher compared with those before Ensure Nutrison nasal feeding（P<0.05）. At 30 d after Ensure Nutrison nasal feeding，the levels of HGB，ALB，TP，PA，TLC，Cr，NB，waist and hip cir－cumferences，levels of MAC and TSF in females were obviously increased compared with those before Ensure Nutrison nasal feeding，but no difference in levels of MAC and TSF was observed in males. There was no obvious increase in gastrointenstional reaction and electrolytes disturbance incidence and the blood glucose was basically normal before and after Ensure Nutrison nasal feeding. Conclusions：Enteral nutrition agent of Ensure Nutrison can improve multiple nutrition indicators of elderly patients with nasal feed－ing without increasing gastrointestinal reactions and electrolyte disorders.