Objective：To know about the changing tendency of anxiety and depression，to probe into influencing factors of breast can－cer during chemotherapy and to discuss intervention measures. Methods：Anderson symptom survey scale and hospital anxiety and de－pression scales were used to evaluate 194 patients with breast cancer who planed to adopt（docetaxel，doxorubicin，cyclophosphamide chemotherapy regimen after operation. Evaluation was made on these patients at least 24 h before chemotherapy and every 5-7 d after chemotherapy. Results：Anxiety and depression levels of patients with breast cancer presented a certain changing tendency，which were the most serious at first，then significantly reduced after the first chemotherapy，but reached the peak after the third chemotherapy，then got better gradually. Anxiety and depression levels were always positive correlated during the whole process of chemotherapy and there were different symptoms affecting anxiety and depression levels at different courses of chemotherapy. Conclu－sions：Nurses should enhance the psychological care for patients with breast cancer during the chemotherapy，give preventative and targeted nursing care to alleviate the patients’ anxiety and depression levels.