Objective：To set up the rat model of chronic intermittent hypoxia（CIH） under normal pressure，to study the relationship between CIH and gastroesophageal reflux disease（GERD） and to explore the effect of CIH on expression of interleukin-6（IL-6） and high sensitivity-C reactive protein（hs-CRP） in rat. Methods：Twenty-four sex maturation rats were randomly divided into unhandled control group（UC group，normal feeding for 4 weeks），CIH group（CIH for 4 weeks），removal of hypoxia group（RH group，normal feeding for 4 weeks after CIH for 4 weeks）. The pH values and the expressions of IL-6 and hs-CRP in the inferior esophageal segment were determined and observed. Results：The inflammation was more obvious in CIH group than in UC group and RH group. The pH values were significantly lowered（P<0.05） and the expressions of IL-6 and hs-CRP were significantly elevated（P<0.01），with no dif－ference between UC group and RH group（P >0.05）. Conclusions：CIH may induce the inflammation change of esophagus and IL-6 and hs-CRP participate in GERD’s development.