Objective：To observe the therapeutic effect of sanyrene liquid dressing on prevention of inevitable pressure sore in high risk patients. Methods：A total of 144 high risk patients with inevitable pressure sore were divided into observational group and control group according to successive hospitalization. Seventy-one patients in observational group used sanyrene liquid dressing to spread the press area while 73 patients in control group used transparency patches. Results：Incidence of inevitable pressure sore was significantly lower and occurring time of pressure sore was later in observational group than in control group. Conclusions：Sanyrene liquid dress－ing can effectively prevent inevitable pressure sore in high risk patients and can be promoted in clinics.