Objective：To preliminary discuss clinical curative effect of octreotide combined with gabexate in the treatment of severe a－cute pancreatitis（SAP）. Methods：Totally 46 patients with SAP from October 2008 to October 2010 in our hospital were randomly di－vided into groups A（n=23） and B（n=23）. Octreotide combined with gabexate were used in group A while only octreotide was used in group B. Patients’ normal time of disappearance of abdominal signs，recovery of gastrointestinal function and recovery of hematuria amylase in two groups were observed. Total effective rate and complication incidence in two groups were observed. Results：Time of abdominal signs’ disappearance，gastrointestinal function’s recovery and hematuria amylase’s recovery were shorter in group A than in group B（P<0.05）. Total effective rate in group A is higher than that in group B，but without significant differences（P<0.05）. Inci－dence of complication and operation rate in group A（13.04%） was lower than that in group B（30.43%）. Conclusions：Octreotide combined with gabexate is the better choice in the treatment of SAP，which can improve the total effective rate and reduce complica－tion incidence.