Objective：To investigate the correlation between QT dispersion（ＱＴd） and serum enzyme changes in patients with acute cerebrovascular disease and to evaluate the diagnosis value of QTd and serum enzyme changes. Methods：Totally 90 patients with acute cerebrovascular disease from February 2011 to January 2012 were served as observation group；90 healthy subjects from February 2011 to January 2012 were served as control group. All patients and healthy subjects received 12-lead electrocardiogram（ECG） and QTd was measured. Commercial kits were used to measure the activity concentration of transferase（AST），lactate dehydrogenase（LDH），α-hydroxybutyrate dehydrogenase（α-HBDH），creatine kinase（CK） and myocardial-type creatine kinase isoenzyme（CK-MB）. Corre－lation analysis of QTd and serum enzymes was performed. Results：Average activity concentrations of serum AST，LDH，α-HBDH and CK of observation group were significantly higher than those of control group（t=10.13，P=0.000；t=12.55，P=0.000；t=13.14，P=0.000；t=20.91，P=0.000），but average activity concentration of myocardial-type CK-MB has no significant difference between the two groups（t=0.88，P=0.378）. Average QTd of observation group was significantly higher than that of control group（t=9.09，P=0.000）. QTd and serum enzymes（AST，LDH，α-HBDH and CK） activity were positively correlated（r=0.913，P=0.001；r=0.923，P=0.002；r=0.727，P=0.021；r=0.823，P=0.017）. Conclusions：QTd and serum enzyme（AST and LDH） activity concentration combined detection has potential clinical value for diagnosis of acute vascular disease.