Objective：To investigate the differences of hepatic lobe volume and distribution in patients with different causes of liver cirrhosis（LC） by measuring caudate lobe volume（CV），left medial liver lobe volume（LMV），left lateral liver lobe volume（LLV），right anterior liver lobe volume（RAV），right posterior liver lobe volume（RPV），left liver lobe volume（LV），right liver lobe volume（RV），and total liver volume（TLV） using 320 slice CT. Methods：A volume CT scan was performed in 107 patients with LC of 4 different causes（alcohol，hepatitis B virus（HBV），cryptogenic and cholestatic cirrhosis）. Volume of the each liver lobe was measured respec－tively，and the total liver volume and the percentage of each lobe in the liver were also calculated. Results：CV，LMV，RAV，RPV，RV，LV and TLV were larger in alcoholic cirrhosis group than in cryptogenic and cholestatic cirrhosis groups（P<0.008 33）. CV was larger in cholestatic cirrhosis group than in HBV cirrhosis group（P=0.000）. CV/TLV was smaller in HBV cirrhosis group than in alcoholic cirrhosis group and cholestatic cirrhosis group（P=0.002，P=0.000）. RPV/TLV was smaller in cholestatic cirrhosis group than in HBV cirrhosis group and alcoholic cirrhosis group（P=0.005，P=0.008）. RPV/RV was smaller in cholestatic cirrhosis group than in HBV cir－rhosis group，alcoholic cirrhosis group and cryptogenic cirrhosis group（P=0.001，P=0.005，P=0.006）. Conclusions：There are differences in the changes of the hepatic lobe volume and distribution in patients with different causes of LC by the quantitative analysis of liver lobes volume using 320 slice CT.Changes of the hepatic volume are correlated with the causes of liver cirrhosis.