Objective：To investigate the life quality and influencing factors among drug users receiving methadone maintenance treat－ment and to provide references for targeted mental intervention. Methods：Drug users receiving methadone maintenance treatment in Nanchang were selected by convenience cluster sampling and were surveyed with questionnaires including self-rating anxiety scale（SAS），self-rating depression scale（SDS），general quality of life inventory-74（GQOLI-74） and self-made general questionnaire. Results：Mean score of GQOLI-74 was 48.96±5.00.There were significant differences among factors of education，character，self-con－sidered economic condition and economic pressure（F=4.877，F=6.481，F=8.934，F=6.162，P<0.05），but there was no significant differ－ence among factors of gender（t=-1.034，P=0.302），profession（t=0.348，P=0.728），living condition（F=1.049，P=0.382），marital status （F=1.955，P=0.101）and specific family income（F=0.725，P=0.485）. Multivariate linear stepwise regression indicated that the main in－fluencing factors of GQOLI-74 total score were relationship with parents and neighbors，fulfillment of family obligations，correct an－swer rate to AIDS knowledge and awareness and standard score of SAS. Conclusions：Life quality among drug users receiving methadone maintenance treatment is low，more love and attention are needed and targeted intervention measures should be taken to improve their life quality.