Objective：To compare three different procedures，including percutaneous transcatheter closure，open-heart surgery and transthoracic minimally invasive surgery and to analyze which procedure is possibly the best option in treatment of ventricular septal defect（VSD） in children. Methods：The study involved 250 children with VSD in our hospital during the period from January 1，2011 to December 31，2011. One hundred and twenty-three children were treated by percutaneous transcatheter closure（transcatheter group），104 by traditional open-heart surgery（open-heart group） and 23 by transthoracic minimally invasive surgery（minimally inva－sive surgery group）. Results：Operation time，volume of blood transfusion，postoperative ventilation duration，intensive care unit（ICU） care duration，hospitalized duration were significantly longer in open-heart group than in transcatheter group and minimally inva－sive surgery group（P<0.001）. Blood transfusion，mechanical ventilation and ICU care were unneeded in transcatheter group. Opera－tion time and postoperative hospitalized duration in minimally invasive surgery group were significantly longer than those in tran－scatheter group（P<0.001）. There was no statistical difference in operation success rate and major complication incidences among three groups（P >0.05）. Conclusions：Three procedures are all safe and effective in treating VSD. Condition should be fully assessed and right procedure should be chosen according to different indications.