Objective：To explore the clinical value of prenatal ultrasonic examination in screening out fetal malformations. Methods：Pregnant women’s ultrasonic examination results in 2012 were analyzed retrospectively. Detection rate，systemmatic distribu－tion and severity of fetal malformations were calculated. Results：A total of 32 667 pregnant women underwent ultrasonography. Detection rate of fetal malformations was 1.27%（414/32 667）. Cardiovascular system malformation was most common（23.43%，97/414），followed by nervous system malformation（17.15%，71/414）. Rate of serious deformations was 54.59%（226/414），most common in nervous system malformation（27.88%，63/226）. Conclusions：Prenatal ultrasonic examination is of great clinical value in screen－ing out fetal malformation and reducing birth birth defects.