Objective：To investigate the practical value of CT angiography（CTA） in laparoscopic splenectomy（LS） with amputation of secondary structures of the spleen peclicel. Methods：Clinical records of 62 patients with idiopathic thrombocytopenic purpura（ITP） were retrospectively analyzed. Clinical data of patients underwent CTA scan（CTA group） and those did not underwent CTA scan but did LS（control group） were compared. Results：Operative time was （185.58±14.09） min and （215.00±22.01） min in CTA group and control group，Intraoperative blood loss was （165.78±88.42） ml and （262.78±80.70） ml，postoperative hospital stay was （8.46±1.48） d and （10.14±1.51） d，with statistical significances（P<0.05）. Conclusions：Anatomical structure of spleen blood ves－sels and their relationship with pancreas can be mastered before surgery in CTA group，which can guide better dissection of spleen blood vessels in surgery and also contribute to Hem-O-lok ligation and cut off of the blood vessels using harmonic scalpel rather than using Endo-GIA. CTA group displays shorter operative time，less bleeding and shorter hospital stay than control group. Therefore，CTA scan is of clinical valuable for ITP patients who need the treatment of LS.