In this study，application and relationship between multislice CT（MSCT） pulmonary functional imaging technology and pulmonary function test in patients with airway lesions were reviewed. First，airway lesions and its causes in patients with chronic ob－structive pulmonary disease（COPD） were elaborated. Then limitation of traditional evaluation method for airway lesion（pulmonary function test） was analyzed. On this basis，function and advantages of MSCT was evaluated. Comprehensive analysis was conducted on the relationship between results of MSCT pulmonary functional imaging technology and pulmonary function test by referring to findings of other scholars. Use of MSCT provides a favorable basis and valuable information for quantitative evaluation of patients with COPD airway lesions. MSCT pulmonary functional imaging technology has significant correlation with pulmonary function test and can reflect airway disease preferably. It is an effective imaging tool for diagnozing COPD and evaluating pulmonary functional level.