Objective：To observe the effects of integrated care intervention on psychology and immunity of patients with cervical can－cer（CC） in order to establish a clinical interventions system to guide nursing care. Methods：Totally 128 patients with CC were select－ed from May 2009 to February 2012 in our hospital and were divided into psychological intervention group（observation group） and usual care group（control group）. Postoperative psychological characteristics and associated immune indicators of patients were ana－lyzed. Results：After the intervention，self-rating depression scale（SDS） and self-rating anxiety scale（SAS） scores of observation group were significantly lower （SDS：t=6.821，P=0.000；SAS：t=4.803，P=0.000） and those of control group remained the same（SDS：t=1.570，P=0.146；SAS：t=0.939，P=0.382）. Two scores in observation group were significantly lower than those in control group（SDS：t=5.415，P=0.000；SAS：t=4.299，P=0.000）. T lymphocyte subsets CD3+，CD4+，CD8+ and CD4+/CD8+ ratio were improved at varying de－grees in both groups，but the effects were significantly better in observation group than in control group（t=7.959，P=0.000；t=2.543，P=0.015；t=2.983，P=0.004；t=2.778，P=0.007；t=5.479，P=0.000）. Conclusions：Clinical care combined with psychological intervention can significantly improve mental health and immunity，enhance treatment outcome，promote prognosis for patients with CC，besides，it is important for clinical nursing care.