Objective：To investigate the curative effect and postoperative complications of the third ventricle craniopharyngioma re－moved by transcallosal-stptum pellucidum-interforniceal approach. Methods：Clinical data of 28 patients with the third ventrile cran－iopharyngioma undergoing transcallosal-septum pellucidum-interforniceal approach resection were analyzed retrospectively. Results：Total tumor removal was achieved in 18 cases，subtotal removal in 6 cases and partial removal in 4 cases. Electrolyte disorder and diabetes insipidus were observed in most of the cases.Other frequent complications included endocrine disorders，mutism，hyperpyrexia and seizures. Conclusions：Transcallosal-septum pellucidum-interforniceal approach is the best choice for the resection of the third ventricle craniopharyngioma. Postoperative complication is common and serious，sufficient preoperative preparation and good periop－erative management is the premise of the successful operation.