Invasion of extravillous trophoblasts（EVT） is fundamental to the development of placenta during early pregnancy. Being regulated precisely by the secretions of trophoblasts and other cells，trophoblast invasion is also mediated by signaling pathways and regulatory transcription factors. Any factor leading to these regulations uncontrolled will induce dysfunction of trophoblast in gestational diseases such as preeclampsia and fetal growth restriction. This article reviewed the literatures in recent years about molecular regula－tion of human trophoblast invasion，which will improve our understanding about the role of the trophoblasts in gestational diseases such as preeclampsia and other pregnancy complications with incomplete spiral artery remodeling and provide new ideas for the stud－ies of pathogenesis and treatments of these disorders.