Objective：To observe the clinical efficacy of CO2 laser combined with pingyangmycin for laryngeal contact granuloma. Methods：Clinical data of 18 cases of laryngeal contact granuloma diagnosed from January 2011 to December 2012 in our hospital were retrospectively analyzed. All 18 patients had 22 times treatment history. Among them，9 patients were treated by CO2 laser op－eration combined with pingyangmycin（group 1） while 13 patients were treated by single CO2 laser operation（group 2）. All patients were followed up over 6 months after the operation. Results：The one-time curative rate was 100% in group 1 and was 53.8% in group 2. 7 cases were cured and 6 cases experienced recurrence. The relapse rate of CO2 laser operation combined with pingyang-mycin was lower than that of single CO2 laser operation（P<0.05）. Conclusion：Laryngeal contact granuloma has a strong tendency to recur. The reason of occurrence and recurrence may relate with a large number of fiber cells and vascular proliferation. For recurrent patients，CO2 laser combined with pingyangmycin leads to vascular occlusion and granuloma growth inhibition；therefore can signifi－cantly reduce the recurrence rate.