Objective：To study the effects of endotracheal tube occluder made from disposable infusion apparatus. Methods：Sixty-two patients underwent tracheotomy due to pulmonary contusion and respiratory insufficiency were enrolled and divided into two group according to different occluders. Thirty-seven patients in control group were treated with traditional occluders while 25 patients in ex－periment group were treated with occluders made from dispos－able infusion apparatus. The time for closing endotracheal tube，occluder drop incidence，secondary infection and the occurrence of airway foreign body were compared. Results：Experiment group showed a shorter time for closing endotracheal tube（Z=6.7，P=0.000） and a lower incidence of occluder drop compared with those of control group（P=0.017）. There was no difference between the two groups in secondary infection and the occurrence of airway foreign body（P >0.05）. Conclusion：The new endotracheal tube occluder made from disposable infusion apparatus overcomes defects of the traditional occluder. It has the potential to be widely used in clinic work.