Objective：To observe the therapeutic effect of improved ACH-10 Asahi Kasei on multiple organ dysfunction syndrome （MODS） in hemofiltration of low birth weight children. Methods：Ongoing continuous venous hemofiltration（CVVHF） by ACH-10 Asahi Kasei was performed on eight low birth weight children with severe MODS. Changes in blood pressure，serum potassium，urea nitrogen，creatinine，lactate，and prognosis were observed. Results：Catheterization and bypass were successfully performed on eight low birth weight children. Blood sampling was not well in all cases，but still successfully bypassed through diluting by the pump. Internal environment disorder and renal function were improved significantly. There was one hypothermia child and one hypotension child after the operation and they were improved after the treatment. No child with lower blood pressure and other complications was observed. Conclusion：Appropriately modified Asahi Kasei ACH-10 can be used in blood hemofiltration for low birth weight children and will help to improve the function of serious important organs of MODS children with low birth weight as well as improve the success rate.