Objective：To evaluate the application characteristics of glucocorticoid after liver transplantation in the treatment of autoim－mune hepatitis（AIH）. Methods：All data was collected from the First Affiliated Hospital of Chongqing Medical University and West China Hospital of Sichuan University，including 99 adult patients with liver transplantation（from January 2005 to January 2012）. All patients were assigned to two groups：36 cases with AIH（observation group） and 63 cases without AIH（control group）. Differences in perioperative parameters and glucocorticoid usages between the two groups were observed. Results：In order to combat rejection，liver and various organ functions remained stable. Glucocorticoid usage was significantly larger in observation group than in control group（P=0.000）. Dosage of glucocorticoid was significantly higher in observation group than in control group（（17.8±5.3） mg/d vs. （9.4±3.9） mg/d）. Duration of using glucocorticoid was significantly longer in observation group than in control group. （385.2±21.7） d vs. （47.1±11.3） d）（P=0.000）. Conclusion：Long-term application of glucocorticoid during immune rejection period can improve trans－plant outcome during immune rejection period for AIH.