Objective：To investigate the curative effect of ureteral occlusion device combined with holmium laser in the treatment of upper or middle urethral stones. Methods：Clinical data of 32 patients with upper or middle urethral calculi were analyzed retrospec－tively. Effects of stone cleaning and intra-opertive complication were observed. Results：One patient used flexible ureteroscope and holmium laser lithotripsy due to the migration of calculi into renal calices，with calculi migration rate of 3.2%. Urethral occlusion de－vice was set successfully in other thirty-one cases. There was neither perioperative mucous membrane nor urethra perforation. At one month postoperatively，one patient can not remove calculi in the renal calices and all other patients had no calculi residual，with clearance rate of 96.8%. Conclusion：Urethral occlusion device can significantly decrease calculi migration during lithotrity process in the upper or middle urethra and can improve calculi clearance rate，therefore has satisfactory clinical value.