Objective：To observe the therapeutic effect of sanyrene on prevention of skin injury caused by abnormal defecation in high risk patients. Methods：A total of 157 high risk patients with abnormal defecation were randomly divided into observational group and control group. Seventy-nine patients in observational group used sanyrene liquid dressing to spray the crissum and hip area after using warm water to clean，while 78 patients in control group used warm water to clean. Results：There were statistically significant differences in the occurrence rate of crissum skin injury between the two groups；lower in observational group than in control group. Conclusion：Sanyrene can effectively prevent skin injury caused by abnormal defecation in high risk patients and can be promoted in clinics.