Objective：To investigate the peripheral blood of von Willebrand factor-cleaving protease（vWF-cp） levels in patients with coronary heart disease（CHD） and its correlation with global registry of acute coronary events（GRACE） score then to assess the risk of CHD with the combination of them. Methods：Totally 145 patients who underwent coronary angiography were selected as research subjects. They were divided into three groups by coronary angiography：49 patients with non-coronary heart disease as control group；47 patients with stable angina（SAP） as SAP group；49 patients with acute coronary syndrome（ACS） as ACS group. All patients were scored by GRACE system and then layered. Meanwhile，degree of coronary artery stenosis was assessed by Gensini scoring system and vWF-cp level was measured by ELISA. Results：vWF-cp levels in control group were strikingly higher than those in ACS group（P=0.000） and also higher than those in SAP group（P=0.000）；vWF-cp levels in ACS group were obviously decreased compared with those in SAP group（P=0.023）. GRACE scores in ACS and SAP groups were increased compared with those in control group（P=0.000）（P=0.008）；GRACE score in ACS group was increased compared with that in SAP group（P=0.033）. There was no significant difference in vWF-cp level among CHD patients with different Gensini scores（r=0.060，P＝0.６１６），but GRACE score was negatively correlated with vWF-cp levels（r=-0.672，P=0.000）. Conclusion：Combination of GRACE score and vWF-cp levels could predict risk and progno－sis in patients with CHD accurately and efficiently.