Objective：To observe the clinical outcome of minimally invasive surgical closure treatment for infants with atrial septal de－fect（ASD） and ventricular septal defect（VSD）. Methods：There were 76 patients，who received minimally invasive surgical closure under transesophageal echocardiography. The operation time，duration of hospital stays，and complications were counted and analyzed. Results：The operations were smoothly for all 76 patients without any case of death and occluder falling off. Twenty-eight patients suf－fered from ASD with age of 6 months to 12 years，average body weight of 13 kg，average hospital stay of 10 d，average operation time of 75 min and average time using ventilator of 193 min after the operation. The echocardiography showed that the position of the oc－cluder was good without residual shunt or arrhythmia. Forty-eight patients suffered from VSD with age of 1-12 years，average body weight of 15 kg，average hospital stay of 11 d，average operation time of 93 min，average time using ventilator of 170 min after the operation. The echocardiography showed that the position of the occluder was good；46 patients had no residual shunt and two patents had very little shunt；one patient had premature ventricular premature beat and one patient had incomplete right bundle branch block. Conclusion：With the advantages of maturity，small damage，quick recovery，few complications，high safety and effectiveness，the mini－mally invasive surgical closure treatment is suitable for the infants with ASD and VSD at all agesperiods.