Objective：To study methods of modeling of fluid-structure interaction model of complex intracranial aneurysms. Methods：The original data series of left internal carotid artery spiral giant fusiform aneurysm in a patient were got by 3D cerebral angiography. The original data series was processed to obtain a surface model of STL format of the aneurysm’s vessel segment using MIMICS 12.0.The surface model was imported into Geomagic Studio 12 and was processed to get double NURBES surfaces，which were processed to get the fluid-structure interaction model of internal carotid artery aneurysm using UGS NX 8.0. The model was imported into ANSYS Workbench 14.0 and fluid-structure interaction calculation was performed to evaluate its reliability. Results：A fluid-structure inter－action model was built rapidly and quickly，which was almost the same as actual entities of the patient and was good for fluid-struc－ture interaction analysis. Conclusion：In combination with MIMICS 12.0，Geomagic Studio 12 and UGS NX 8.0，reliable fluid-structure interaction model of complex intracranial aneurysms can be quickly built. This provides a reliable method for the numerical simulation of cerebrovascular disease.