Objective：To observe the acting time of postoperative analgesic effects after applying Parecoxib sodium combined scalp nerve block and to explore whether scalp nerve block combined with Parecoxib sodium is a good analgesic method for craniotomy. Methods：Totally 60 craniotomy patients were randomly divided into scalp nerve block group（control group） and scalp nerve block combined with Parecoxib sodium group（experimental group）. Based on the location of incision，the supraorbital nerve，auriculotempo－ral nerve，greater occipital and lesser occipital nerve were selectively blocked with 0.5% ropivacaine. In experimental group，Parecoxib sodium was given before surgery. Postoperative pain score，sedation score，nausea and vomiting score，vital signs were recorded at 0，1，2，4，12，24 h postoperatively. Results：In experimental group，the analgesic effect acted for 18 h and exerted slight effect on respi－ratory depression，sedation and vital signs. In control group，Parecoxib sodium combined scalp nerve block extended the rescue anal－gesic time，but did not change the dose used. Conclusion：Parecoxib sodium combined scalp nerve block is a good neurosurgical post－operative analgesia method，which might be widely used.