Objective：To summarize the treatment and nursing for hematopoietic stem cell transplantation with Wiskott-Aldrich syn－drome（WAS）. Methods：Treatment and nursing data of 29 patients with WAS who received hematopoietic stem cell transplantation in our hospital from June 2007 to December 2014 were summarized，including reverse isolation，strengthening basic nursing，treatment and nursing of graft versus host disease，infection prevention and control，observation and nursing of hemorrhage，diet nursing，psycho－logical nursing，health education，etc. Results：All 29 patients with WAS who received hematopoietic stem cell transplantation acquired immune reconstitution after careful treatment and care. The follow-up lasted for 2 months to 7 years；22 cases survived with healthy. Conclusion：The keys of success with hematopoietic stem cell transplantation of WAS are the prevention of graft versus host disease and control of infection and nursing.