Objective: To comprehensively evaluate the influence of thalassaemia pregnancy outcomes on pregnant woman

and to provide basis for making clinical decision. Methods: Mediterranean anemia and pregnancy outcomes of pregnant women cohort study from January 1980 to October 2014 were collected. The databases of Chinese Biomedical Literature Database

CNKI database

WanFang

VIP

Medline

ISI Web of knowledge

Elsevier

EMBase and the Cochrane library were retrieved. RevMan5.2 software was used to improve the comprehensive quantitative analysis; subgroup analysis methods were adopted to analyze the source of the heterogeneity

and the funnel chart analysis publication bias was used. Results: The Mediterranean anemia was a risk factor for pregnant women with cesarean section and premature birth(RR=1.35

95%CI[1.19

1.54]，P=0.00; RR=2.06，95%CI[1.29

3.28]，P=0.00)， not a risk factor for neonatal low weight（RR=1.56，95%CI[0.98

2.49]，P=0.06）. Based on subgroup analysis

alpha thalassaemia was not a risk factor for pregnant women with cesarean section

premature birth and low weight（RR=1.32，95%CI[0.92

1.91]，P=0.14;RR=1.21

95%CI[0.51

2.86]

P=0.67；RR=1.27

95%CI[0.52

3.10]，P=0.59）. Beta thalassaemia was not a risk factor for preterm delivery of pregnant women（RR=2.53，95%CI[0.78

8.18]，P=0.12）. Beta thalassaemia was a risk factor for low cesarean section and neonatal weight

and risk are respectively 1.54 times and 2.31 times higher than normal pregnant women（RR=1.54，95%CI[1.20

1.97]，P=0.00；RR=2.31，95%CI[1.04

5.14]，P=0.04）.Conclusion: Thalassaemia is a risk factor for pregnant with cutting palace and preterm delivery

and beta thalassaemia is a risk factor for low cesarean section and neonatal weight.