Objective：To investigate the effect of curcumin on expression of phosphoinositide-3-kinases-γ（PI3K-γ） in sepsis induced myocardial dysfunction（SIMD） mice． Methods：The 60 male c57bl/6 mice were randomly divided into control（Con），sepsis（Sep），curcumin（Cur） and DMSO groups（n=15 per group） by completely randomized digital table study. Mouse SIMD model was in－duced by intraperitoneal injection of 10 mg/kg lipopolysaccharide（LPS）. Mice in Cur group were injected with 200 mg/kg curcumin at 30 min after LPS administration；those in Con and Sep groups with an equal volume of sterile saline solution and those in DMSO group with an equal volume of DMSO． The left ventricular systolic pressure（LVSP），left ventricular end-diastolic pressure（LVEDP） as well as mximum rate of left ventricular pressure development and decay（LV±dp/dt-max） in various groups were monitored by BL-410 multiple monitor in the right carotid artery. Histopathological changes of cardiac muscles were observed by HE staining. The expression of cTnⅠ and TNF-α in serum was detected by ELISA and the expression of PI3K-γ and p-akt in cardiac muscles by Western blot． Results：Compared with those in Sep group，values of LVSP，LVEDP and LV±dp/dt-max at various time points were increased significantly（P=0.000），histopathological changes of cardiac muscles were relieved significantly，the expression levels of PI3K-γ in cardiac muscles were reduced significantly（P=0.000），the expression levels of p-akt protein were increased（P=0.000），and mouse serum cTnⅠ and TNF-α levels were decreased significantly（P=0.000，P=0.000） in Cur group. However，no significant difference was observed between the indexes in DMSO and Sep groups（P=0.586）． Conclusion：The protective effect of curcumin on cardiac muscles of SIMD mice is associated with the inhibition of PI3K-γ expression.