Objective：To explore the effects of cluster based care intervention on depression tendency of empty-nesters in nursing center. Methods：Totally 54 cases of empty-nesters were employed to do cluster based care. GDS was used before and after the inter－vention. Results：The empty-nesters depression detection rate was 22.22% before the intervention and was 7.41% after the intervention（P=0.021）. There were significant differences in GDS scores before and after intervention（P=0.000）. High and medium sections of the GDS scores significantly decreased after the intervention（P=0.000），while low section of GDS scores had no significant difference before and after the intervention（P=0.061）. Conclusion：Depression is common among empty-nesters. Cluster based care can signif－icantly reduce its incidence and tendency，especially effective for those empty-nesters who had high and medium GDS scores.