Objective：To investigate the expressions of fibronectin（FN） and phosphatase and tensin homology deleted on chromosome ten（PTEN） in hepatocellular carcinoma（HCC） tissue and its clinical significance. Methods：Totally 215 cases of HCC（paraneoplastic tissues） and 19 cases of normal liver tissues were collected. The expressions of FN and PTEN mRNA and protein were detected by RT-PCR，Western blot and immunohistochemical SP method respectively. The correlation between the expressions of FN and PTEN and clinicopathologic features of HCC was analyzed. Results：The expressions of FN mRNA and protein in hepatocellular carcinoma tissue were significantly higher than those in paraneoplastic and normal liver tissue. The expressions of PTEN were significantly lower than those in paraneoplastic and normal liver tissue（F=142.334，P=0.000）. And the expression in paraneoplastic tissues was obviously lower than that in normal liver tissue（F=80.861，P=0.000）. The survival time of FN positive expression group was shorter than that of negative groups；the survival time of PTEN positive expression group was longer than that of negative group；both had statistical sig－nificances after one year（P<0.05）. Conclusion：FN and PTEN ae abnormally expressed in HCC tissue，which might play a promoting or inhibiting effect in the occurrence，development，invasion and metastasis of HCC.