With the development of modern lifestyle and alteration of eating habits，the core of disease spectrum has gradually turned into chronic non-infectious diseases. Cardiovascular disease，lipid metabolism disorders，obesity，metabolic syndrome，polycystic ovary syndrome are associated with insulin resistance in recent studies. Insulin resistance is an important part of chronic non-infectious dis－eases，which will seriously influence the quality of life. Zinc-α2-glycoprotein（ZAG） is a newly discovered adipocytokine. Because of its important role of weight controlling and insulin sensitivity improving，lots of clinical studies have been performed to prove the as－sociation between ZAG and insulin resistance diseases in recent years.