Objective：To investigate the efficacy of procedural sedation under the guidance of intracranial pressure monitoring in the treatment of severe craniocerebral injury. Methods：Totally 300 patients in our hospital from July 2006 to July 2014 were divided into 3 groups（conventional group，sedation group and combination group）. Glasgow coma score（GCS） before and after the treatment，hos－pitalization days，mini-mental status examination scale（MMSE） score，Barthel index（ＢＩ） score，rebleeding，mortality，lung infection data were recorded and Excel database was established. Rebleeding，mortality and lung infection rates of three groups were compared using χ2 test；GCS difference，hospitalization days，MMSE score and BI score were analyzed using analysis of variance. Results：There were statistically significant differences in all indicators mentioned above among three groups. GCS difference were significantly dif－ferent between conventional group，sedative group and combination group（P<0.05）. There were statistically significant differences in hospitalization days，MMSE score，BI score and mortality between sedative group and combination group（P<0.05）. There were statisti－cally significant differences in rebleeding rate and lung infection rate between sedative group and conventional group（P<0.05）. Con－clusion：intracranial pressure monitoring procedural sedation is more conducive to improving the prognosis of severe traumatic brain injury，shortening treatment time and reducing lung infection and bleeding in patients.