Zhang Linglin, Leng Junyan, Zhang Jie, et al. Randomized controlled trials of the point application therapy for stable angina pectoris:a systematic analysis[J]. Journal of Chongqing Medical University, 2015,40(4):527-532.
Zhang Linglin, Leng Junyan, Zhang Jie, et al. Randomized controlled trials of the point application therapy for stable angina pectoris:a systematic analysis[J]. Journal of Chongqing Medical University, 2015,40(4):527-532.DOI:
目的:评价穴位敷贴治疗稳定性心绞痛的疗效及安全性。方法:检索PubMed、Cochrane图书馆、Clinical trials、MED-LINE等英文数据库,以及万方数字化期刊全文数据库、中国生物医学文献期刊数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)。根据纳入、排除标准筛选并纳入符合穴位敷贴辅助治疗稳定性心绞痛的随机对照试验,进行质量评价,Meta分析采用Rev Man 5.2软件。结果:共纳入9篇研究,虽都提到随机,仅1篇明确随机方法,所有纳入文献的分配隐藏及盲法等都不清楚。分析结果显示
Objective:To evaluate the effectiveness and safety of point application therapy in treating table angina pectoris(SAP). Methods:An extensive search of 4 English medical databases(PubMed,CochraneLibrary,Clinicaltrials,MEDLINE),and 4 Chinese medical databases(WanFang,CBM,CNKI,VIP) was conducted. Randomized controlled trials(RCTs) in accordance with inclusion and exclusion criteria were included. And quality of enrolled studies was assessed. A Meta-analysis was performed by Review Manager 5.2 software. Results:After researching,a total of 9 RCTs were included. Only one of the included RCTs had a clear random method. The allocation concealment and blinding of all included studies were not sure. There were statistical differences in relieving angina symptoms between point application therapy group and drug therapy group(RR=1.13,95%CI=1.07-1.20,P=0.000). There were statis-tical differences in ECG effect between point application group and western medicine group(RR=1.12,95%CI=1.04-1.20,P=0.002). There were statistical differences in traditional Chinese medicine(TCM) syndrome between two groups(RR=1.14,95%CI=1.05-1.25,P=0.004). In addition,3 trials reported adverse effects such as skin rash,gastrointestinal adverse reactions. Conclusion:The point application therapy appears to have beneficial effects on relieving angina symptoms and TCM syndromes in participants with SAP. However,the findings should be interpreted with caution due to the poor methodological quality and small sample of the included trials.
关键词
穴位敷贴疗法稳定性心绞痛随机对照试验系统评价Meta分析
Keywords
point application therapystable angina pectorisrandomized controlled trialssystematic reviewMeta analysis