Objective：To evaluate the effect of peer education on patients with stroke. Methods：Totally 80 hospitalized stroke patients in department of neurology were randomly divided into the observation group and the control group，each with 40 cases. The observa－tion group received peer education and the control group received routine health education. The effect was evaluated after 6 months. Results：The observation group showed significantly greater improvement in the knowledge level，physiological function，physical role，vitality，body pain，general health and emotional function after the intervention（P=0.000，P=0.000，P=0.000，P=0.020，P=0.000，P=0.001，P=0.002）. The knowledge level and health status in the observation group were significantly better than those in the control group（P=0.001，P=0.023，P=0.004，P=0.020，P=0.042，P=0.021，P=0.023）. Conclusion：Peer education is beneficial to promoting the knowl－edge level of patients with stroke and improving their quality of lives. It is an effective and feasible health education form.