Due to ultrasound-driven sonodynamic therapy has the advantages of non-invasiveness

targeting and tissue penetration

and significantly enhances the tumor treatment effect

it has a good application prospect in tumor prevention and treatment. At present

there is still a lack of overview of the effect of ultrasonic mechanical force in the mechanism research of sonodynamic therapy. Therefore

we review the current research progress of sonodynamic therapy in vivo and in vitro

integrate the mechanism of sonodynamic therapy in mechanical force

and provide readers with mechanistic force insights into the potential of sonodynamic therapy in cancer treatment.