objective By establishing silicosis rat model

To study the ultrasonographic manifestations of lung lesions in silicosis rat model

To investigate the feasibility of ultrasonic examination in silicosis rat model.method Seventeen SPF SD rats were selected

and 1ml sterile silica dust suspension was injected into the trachea of the rats by non-exposure dust contamination method to establish silicosis rat model.Dye dust before

All rats were examined by lung ultrasound

Ultrasound findings of lung were recorded (Pleural line、b lines、 surrounding lung tissue)

And retain the image；Lung HRCT was performed

images were retained

and lung conditions were observed. One month after dust exposure

all rats were examined by lung ultrasound and HRCT with the same method. Then the rats were sacrificed and their lung tissues were collected for pathological specimens

which were stained by HE and Masson and observed under light microscope.result Dye dust before

ultrasonic display：The sonogram of all rats showed smooth pleural line with good continuity

no increase of B line and no lesion of peripulmonary tissue；HRCT performance：Image quality is poor and lung texture is blurred.After 1 month of dust exposure

ultrasonic display：Compared with before dust exposure

9 rats (52.94%) had hypoechoic clusters around lung tissue；14 rats (82.35%) showed increased B line；Pleural line thickening was detected in 17 rats (100%)

and the difference was statistically significant before and after dust (P lt; 0.05)；14 rats (82.35%) were found to have blurred and irregular pleural lines with discontinuity.HRCT performance：The image quality is poor and the lung texture is blurred.The outline of the large lesion in the lung can be displayed

the details are not clear

and the small lesion is difficult to display.pathology results:Under light microscope

the normal structure of lung tissue in rats was destroyed

alveolar septum was thickened

cellular silicon nodules were formed

fibrous tissue hyperplasia and collagen fiber deposition increased.conclusion Ultrasonographic examination of the lungs of silicosis rats can be found abnormal changes in the pleural line

increased B line

low echoic mass around the lungs and other characteristic sonographic findings

It is concluded that ultrasonography is feasible in silicosis rat model.