Abstract Objective To observe the ultrasound manifestations of calcium pyrophosphate deposition disease (CPPD) and gouty arthritis (GA)

and to explore the application value of ultrasound in differentiating CPPD from GA. Methods The general data and ultrasound findings of 82 CPPD patients and 61 GA patients in our hospital were collected

and the differences between the two groups were compared. Results CPPD and GA were different in age and gender (P<0.05)

women with CPPD were more common

men with GA were more common

and elderly patients with CPDD (>65 years old). The most common site of CPPD is the knee joint

and the most common site of GA is the first metatarsophalangeal joint. The number of people involved in polyarticular joints in GA group was more than that in CPPD group

but CPPD had a more symmetrical tendency of involvement (P<0.05). The CPPD group had a higher incidence of cartilage calcification

a higher incidence of GA double-track sign

bone erosion

tophi

tendon and ligament hyperechoic incidence (P < 0.05)

but no significant difference in synovial hyperechoic incidence between the two groups(P>0.05).The incidences of meniscus degeneration

cartilage damage

bone cortical irregularity

bursitis

synovial thickening

and soft tissue swelling were significantly different between the two groups (P< 0.05)

tenosynovitis

hydrocele

and tendinopathy had no significant difference (P>0.05). Conclusion Ultrasound can clearly show the structural abnormalities of CPPD and GA joints

which can provide reference for clinical diagnosis.